Master’s Thesis on Estimating Effectiveness of Phenolic Extract of Astragalus Hamosus L Root.

Al- Iraqia University College of Education discussed a master’s thesis on estimating the effectiveness of phenolic extract of roots of the plant (Astragalus hamosus L) in stimulating the immune system against some types of cancer cells and bacterial isolates, on Monday 10/10/2022.

The thesis presented by the student Aseel Abdel-Sattar Jubouri from Department of Life Sciences aimed to study the effect of the inhibitory activity of phenolic extract against two types of cancer cells AMJ13 and SK-GT-4, and to study its effect on blood images, lipids, liver and kidney functions in laboratory mice, and study Toxicity of phenolic extract on laboratory mice, and evaluation of the antibacterial effect of phenolic extract on the effect of continuous change in biofilm composition of Staphylococcus aureus and Klebsiella pneumoniae bacteria using four pathogenic strains.

The study concluded that phenolic extract had a significant inhibitory effect against cancer cells, as its toxic effect in AMJ13 (breast cancer cells) was greater than its effect in SK-GT-4 (esophageal cancer cells, and the effect of the extract varied in blood lipid levels, as lipid concentrations decreased and low density. With a clear decrease in cholesterol and increased concentrations of high-density lipids, the phenolic extract of the roots of Astragalus hamosus plant can be considered anti-bacterial due to its ability to inhibit the growth and stop the biofilm formation of some types of pathogenic bacteria at relatively low concentrations.

*The Thesis has given A-Plus.